Alfred Garfall, M.D.

Former M.D. Student

Alfred Garfall

Current Position

Fellow in Hematology & Oncology
Hospital of the University of Pennsylvania

 

 

Education and Training

Undergraduate/Graduate

  • 2008: M.D., NYU School of Medicine
  • 2002: B.A. in Molecular Biology, Princeton University

Previous Work

Sonic Hedgehog (Shh) is required in the telencephalon for the formation of the most ventral structures as well as the dorsal midline. The role of Shh in patterning these structures is, in large part, modulated as Shh antagonizes the activity of two proteins: Pax6 and Gli3-repressor (Gli3-R). Downstream of their interaction with Shh, however, it is unclear how Pax6 and Gli3-R interact in dorsal/ventral patterning. Since genetic analysis of this interaction in the mouse telencephalon has been difficult, I am examining this interaction in the mouse spinal cord, where development is analogous in many ways to development in the telencephalon.