Robert Machold, Ph.D.

Director, PPG Transgenic Core

Robert Machold

Contact Information

Phone: 212.263.9140
Fax: 212.263.9170
EmailRobert.Machold@nyumc.org

Education and Training

Undergraduate/Graduate

  • 1997: Ph.D. in Biology, M.I.T., Hidde Ploegh Lab
    ​(now at Whitehead Institute)
  • 1991: B.S. in Molecular Biophysics and Biochemistry, Yale University
     

Current Study

At present, I am studying the early embryonic development of the cerebellum, with a focus on the molecular signaling events that lead to the segregation of rhombic lip derivatives from the ventricular neuroepithelium. Through a combination of technical approaches including transgenic and retroviral mediated gain-of-function, as well as conditional loss-of-function, I have found that Notch signaling plays a crucial role in maintaining a ventricular progenitor population, and may act by antagonizing rhombic lip derived signals such as BMPs. Utilizing the chick electroporation system, I am currently exploring the epistasis between Notch and BMP signaling that appears to be critical for maintaining the balance between rhombic lip and ventricular germinal zones.